Either increases effects of the other by pharmacodynamic synergism. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Modify Therapy/Monitor Closely. Chandler G, Harchowel J, Macdougall I. Anemias. Observed Hb = the patients current hemoglobin in g/dl. Applies only to oral form of both agents. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Avoid or Use Alternate Drug. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Modify Therapy/Monitor Closely. Total dose iron infusion: safety and efficacy in predialysis patients. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. You can further save the PDF or print it. Anemia caused by the depletion of iron is called iron deficiency anemia. 2. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. This website also contains material copyrighted by 3rd parties. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Venofer is given as an infusion into a vein. You may need extra iron because of blood loss during kidney dialysis. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Copyright 1993-2021 Consult your doctor before breast-feeding. Formula for calculating the required dose of iron sucrose 1. 2.1 . 1. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Human studies not conducted. Use Caution/Monitor. Anemia; 2015: 763576. Applies only to oral form of both agents. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Deferasirox chelates iron. Human studies not conducted. David McAuley, Pharm.D. 1970; 100(7):301-3. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Pain, swelling, or redness at the injection site may occur. Use Caution/Monitor. Administer on 5 different occasions over a 14 day period. Fulminant symptoms include confusion, sensation of passing out, paleness. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. If either is present, do not use the liquid. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Administer Venofer early during the dialysis session (generally within the first hour). Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. 2. Administer while the patient is in a reclined or semi-reclined position. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Mean change in Hgb from baseline to Week 5 2,5 For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Although the original formula requires the weight in kilograms, values input in lbs are transformed. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Applies only to oral form of both agents. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Applies only to oral form of both agents. Applies only to oral form of both agents. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. *Repeat dose if iron deficiency anemia reoccurs. Parenteral iron dextran therapy. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. LBW = Lean body weight in kg. Modify Therapy/Monitor Closely. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Minor/Significance Unknown. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. LBW = Lean body weight in kg. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Applies only to oral form of both agents. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Use Caution/Monitor. Corrected Calcium. Applies only to oral form of both agents. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Use Caution/Monitor. This drug is available at a middle level co-pay. This website is intended for use by US healthcare professionals only. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. 1998 Feb;25(1):65-8. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Use Caution/Monitor. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Applies only to oral form of both agents. https://www.uptodate.com/ (Requires subscription). Comparable efficacy to that of IV iron sucrose. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days.
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